Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40.
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.
The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.
Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.
Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.
S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.
A role for FKBP52 in Tau protein function.
S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle.
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.
The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.
Architecture of the human interactome defines protein communities and disease networks.
The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Quantitative fragmentomics allow affinity mapping of interactomes.
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of Hsp90.
Reactome: FKBP4 in nucleoplasm.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol/nucleoplasm.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in nucleoplasm.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in nucleoplasm.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
Reactome: FKBP4 in cytosol.
UniProt entry Q02790 (FKBP4_HUMAN), Peptidyl-prolyl cis-trans isomerase FKBP4 / FKBP52
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Immunophilin with PPIase and co-chaperone activities; component of steroid receptor heterocomplexes via HSP90; promotes intracellular trafficking of steroid hormone receptors; controls neuronal growth cones via TRPC1; regulates microtubule dynamics via MAPT/tau; cytosolic, mitochondrial, nuclear and cytoskeletal localization.