GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
GO_REF:0000121
RGD ISO annotations to rat from other mammalian species
PMID:10506212
Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor.
PMID:12615969
Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells.
PMID:12676536
Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons.
PMID:12873381
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.
PMID:1311032
Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin.
PMID:15212990
Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices.
PMID:15533917
Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.
PMID:15911880
Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling.
PMID:16014380
Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.
PMID:16223735
Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling.
PMID:17178908
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.
PMID:17285299
Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum.
PMID:17471556
Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus.
PMID:19036964
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
PMID:19236309
Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells.
PMID:20189985
Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.
PMID:20434434
Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors.
PMID:21211516
Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.
PMID:21424589
Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.
PMID:22045699
The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins.
PMID:22547632
Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP.
PMID:23479737
Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.
PMID:23982204
Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor.
PMID:24814243
Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.
PMID:28072885
Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia.
PMID:36376291
Conformational motions and ligand-binding underlying gating and regulation in IP(3)R channel.
Reactome:R-RNO-182052
IP3 binds to the IP3 receptor, opening the Ca2+ channel
Reactome:R-RNO-182097
Calcium release from intracellular stores by IP3 receptor activation
UniProtKB:P29994
UniProt entry ITPR1_RAT
PMID:19845505
Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain.
PMID:21550988
Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptor.
PMID:16793548
IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.
PMID:28598420
Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
PMID:10828023
Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.
file:rat/Itpr1/Itpr1-deep-research-manual.md
Manual literature synthesis for rat Itpr1