Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release.
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Ribosome synthesis begins in the nucleolus with 90S pre-ribosome construction, and the study reports a role for the CMS1/CMSS1-family factor Cms1 in this process.
"Ribosome synthesis begins in the nucleolus with 90S pre-ribosome construction,"
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Cms1 is detected on an early 90S pre-ribosome at the 18S rRNA 3' major domain carrying the H/ACA snoRNA snR83, and co-precipitates with many 90S factors.
"detected Cms1 at the 18S rRNA 3"
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Cms1 is proposed to restrict premature Rrp12-Enp1 binding while allowing snR83 to act, coordinating stepwise local 90S assembly.
"restrict premature Rrp12-Enp1 binding but allows snR83 to"
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The mechanism by which the many snoRNAs that modify pre-rRNA are guided to their target sites during early ribosome assembly is largely unknown, framing Cms1 as a poorly understood coordinating factor.
"little is known about how the many different snoRNAs that modify the"