Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.
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CAR-1 associates with CGH-1 and Y-box proteins in a conserved germline RNP complex
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The CGH-1/CAR-1 interaction is conserved in Drosophila oocytes
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car-1(RNAi) increases physiological germline apoptosis
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CAR-1 is critical for oogenesis
A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.
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CAR-1 contains an atypical Sm domain and RGG box that bind RNA
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CAR-1 forms an RNA-dependent complex with CGH-1 and CEY-2
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CAR-1 localizes to P-granules and smaller cytoplasmic particles
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The Sm domain is essential for CAR-1 function but not localization
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CAR-1 depletion causes failure of interzonal microtubule bundle formation
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CAR-1 depletion prevents AIR-2 and ZEN-4 targeting to spindle midzone
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CGH-1 controls CAR-1 particle localization
CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos.
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CAR-1 colocalizes with DCAP-1 in P-bodies
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CAR-1 localizes to P-granules
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car-1 inhibition causes late cytokinesis failures
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Spindle midzone fails to form in car-1 depleted embryos
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ER organization is disrupted in car-1 depleted embryos
Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.
Maternal mRNAs are regulated by diverse P body-related mRNP granules during early Caenorhabditis elegans development.
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Loss of CAR-1 causes ectopic GLP-1 protein expression in oocytes while glp-1 mRNA levels remain unchanged, indicating CAR-1 controls glp-1 translation rather than mRNA production or stability
"glp-1 mRNA levels were similar in car-1(tm1753) mutant and wild-type animals, which supports CAR-1 control of glp-1 translation rather than mRNA production or stability"
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CAR-1 promotes PUF-dependent translational repression of glp-1 during late oogenesis
PAB-1, a Caenorhabditis elegans poly(A)-binding protein, regulates mRNA metabolism in germline by interacting with CGH-1 and CAR-1.
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PAB-1 colocalizes with CAR-1 in P-granules and P-bodies
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PAB-1, CGH-1, and CAR-1 interact in mRNA metabolism regulation
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CGH-1 controls CAR-1 localization; CAR-1 does not control CGH-1 localization
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PAB-1 affects CGH-1 and CAR-1 localization
Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans.
Falcon (Edison Scientific) deep research report on C. elegans car-1 (Q9XW17)
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CAR-1 is a conserved LSM14/Scd6/Rap55-family RNA-binding protein that
partitions into cytoplasmic RNP condensates (P-bodies/P-body-like foci
and germ granules) and acts as an adaptor/scaffold rather than an enzyme.
"CAR-1 is not an enzyme; it is best annotated as an **RNA-binding mRNP assembly/adaptor protein**"
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CAR-1 directly binds RNA, with its RGG region binding poly(U) in vitro
and an N-terminal Lsm domain consistent with the LSM14/Scd6/Rap55 family.
"RGG region binds poly(U) in vitro, supporting direct RNA-binding capacity."
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CAR-1 promotes translational repression of specific maternal mRNAs,
including PUF-dependent repression of glp-1 in oogenesis.
"In the germline/oogenesis, CAR-1 promotes PUF-dependent repression of the Notch-like receptor mRNA **glp-1**, and car-1 depletion elevates GLP-1 protein while glp-1 mRNA levels remain similar, consistent with primary control at the translation level."
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CAR-1 is required for late embryonic cytokinesis and ER organization;
depletion causes furrow regression and disrupted spindle midzone.
"CAR-1 is required for late cytokinesis/scission; depletion causes cleavage furrows to ingress then regress and disrupts membrane accumulation and spindle midzone organization"
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In neurons, CAR-1/LSM14 represses micu-1 to modulate mitochondrial Ca2+
dynamics and acts as a cell-intrinsic inhibitor of PLM axon regrowth.
"represses neuronal **micu-1**, thereby modulating mitochondrial Ca2+ uptake dynamics after axotomy and acting as a cell-intrinsic inhibitor of PLM axon regrowth."
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CAR-1 contributes a scaffold role to decapping condensates; in
edc-3(0);edc-4(0) embryos car-1 RNAi reduces DCAP-2 foci 2-4.5-fold.
"car-1 RNAi (64% knockdown) in this background reduces DCAP-2 foci 2–4.5-fold, supporting a scaffold role for CAR-1 in alternative condensate frameworks when canonical scaffolds are absent."
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CAR-1 organizes condensate-condensate interactions supporting
piRNA-dependent transgenerational silencing, promoting CGH-1 perinuclear
localization and its binding to PRG-1/WAGO-1.
"CAR-1 promotes CGH-1 perinuclear localization/condensate formation, and CAR-1 depletion reduces CGH-1 binding to PRG-1 and WAGO-1"