GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:15469522

Cladosporium fulvum circumvents the second functional resistance gene homologue at the Cf-4 locus (Hcr9-4E ) by secretion of a stable avr4E isoform.

Hcr9-4D is the functional Cf-4 gene matching Avr4; the neighbouring Hcr9-4E recognises Avr4E.

PMID:23716655

Receptor-like kinase SOBIR1/EVR interacts with receptor-like proteins in plant immunity against fungal infection.

SOBIR1/EVR forms a complex with Cf-4 in planta, stabilises it, and is required for Cf-4-mediated HR and immunity.

PMID:9437864

Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequences that determine recognitional specificity in Cf-4 and Cf-9.

Cf-4 encodes a membrane-anchored extracellular glycoprotein with 25 LRRs, >91% identical to Cf-9; specificity differences lie in the N terminus.

PMID:11226184

Domain swapping and gene shuffling identify sequences required for induction of an Avr-dependent hypersensitive response by the tomato Cf-4 and Cf-9 proteins.

Cf-4 domain B and LRRs 11-12, and LRR copy number, determine Avr4-dependent HR specificity.

PMID:26765243

Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity.

Cf-4 interacts with SOBIR1 at the plasma membrane; Avr4 recruits BAK1/SERK3 and triggers Cf-4 endocytosis to late endosomes.

PMID:15166169

Genetic variation at the tomato Cf-4/Cf-9 locus induced by EMS mutagenesis and intralocus recombination.

PMID:16167771

The Cf-4 and Cf-9 resistance genes against Cladosporium fulvum are conserved in wild tomato species.

file:SOLHA/Cf-4/Cf-4-deep-research-falcon.md

Deep research report on Cf-4 (Falcon)