The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo.
Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease.
Isolated polycystic liver disease genes define effectors of polycystin-1 function.
Novel GANAB variants associated with polycystic liver disease.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
Defining the membrane proteome of NK cells.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
UniProtKB entry Q14697 (GANAB_HUMAN)
Removal of the second glucose by glucosidase II
Removal of the third glucose by glucosidase II and release from the chaperone
N-glycan trimming of Spike
ER-alpha glucosidases bind ER-alpha glucosidase inhibitors
N-glycan glucose trimming of Spike
Glucosidase II removes glucose residue from Glu2Man9GlucNAc2-CDH1
Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
GANAB target evidence in original proteomic tables
Cell type-specific post-Golgi apparatus localization of a "resident" endoplasmic reticulum glycoprotein, glucosidase II.
-
Kidney tubular glucosidase II showed cell-type-dependent post-Golgi distribution, distinct from the previously reported hepatocyte pattern.
"immunoreactivity for glucosidase II predominantly in post-Golgi
apparatus structures"