Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Isolation and characterization of a cDNA clone for human ferritin heavy chain.
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Established that ferritin is the main iron-storage protein composed of H and L subunits
"Ferritin, the main iron-storage protein, is composed of two partially homologous subunits, heavy (H) and light (L)"
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Isolated cDNA clone for human ferritin H chain
"We have isolated a cDNA clone for human ferritin H chains by screening a human lymphocyte cDNA library with synthetic oligodeoxyribonucleotides"
Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene.
Dinuclear center of ferritin: studies of iron binding and oxidation show differences in the two iron sites.
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Demonstrated ferroxidase activity at the dinuclear center within H-type chains
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Developed stopped-flow assay to dissect Fe2+ binding and oxidation
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Showed sequential Fe2+ binding at sites A then B
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Mutagenesis of Glu-28, Lys-87, Glu-108 affected iron binding and oxidation
Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.
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c-MYC represses FTH1 expression to increase labile iron pool
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FTH1 sequesters intracellular iron
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Down-regulation of FTH1 required for c-MYC-mediated cell transformation
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
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NCOA4 directly binds FTH1 to target ferritin to autolysosomes
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Ferritinophagy occurs following starvation or iron depletion
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NCOA4 knockout mice accumulate iron in splenic macrophages
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.
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FTH1 is transcriptionally activated by NRF2
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FTH1 knockdown promotes ferroptosis in response to erastin and sorafenib
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FTH1 is part of the p62-Keap1-NRF2 ferroptosis defense pathway
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)
Recruitment Of Cytoplasmic Proteins To Vesicles
Exocytosis of tertiary granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.
A human protein-protein interaction network: a resource for annotating the proteome.
Towards a proteome-scale map of the human protein-protein interaction network.
The TSC1 gene product hamartin interacts with NADE.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Next-generation sequencing to generate interactome datasets.
FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis.
Proteomic characterization of the human sperm nucleus.
Protein interactome reveals converging molecular pathways among autism disorders.
Toward an understanding of the protein interaction network of the human liver.
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Architecture of the human interactome defines protein communities and disease networks.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Atomic-resolution protein structure determination by cryo-EM.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Deep research report on FTH1