Gene Ontology annotation through association of InterPro records with GO terms
Combined Automated Annotation using Multiple IEA Methods
UniProt entry A0A314KVN4 for Nicotiana attenuata DTX40_3
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DTX40_3 is a membrane-localized MATE-family antiporter
"CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family."
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UniProt places DTX40_3 in membrane and multi-pass membrane protein annotations
"CC -!- SUBCELLULAR LOCATION: Membrane"
NaMATE1 DTX40_3 candidate notes
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MATE1 is genomically and expression-linked to the late nicotine pathway module
"The glucosylation preprint identifies an A622-MATE1-beta-GD1 cluster, reports that these genes are root enriched and tightly co-expressed with nicotine biosynthesis genes, and keeps MATE1 in the core late-pathway module even though the exact transported metabolite remains unresolved."
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DTX40_3 is the best current sequence-backed NICAT ortholog to tobacco MATE1
"The 2026-04-05 mapping dive assigns NaMATE1 to DTX40_3 / A0A314KVN4 as the best current sequence-backed NICAT ortholog to tobacco MATE1."
Deep research report on NaMATE1/DTX40_3 (Falcon/Edison Scientific Literature)
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No primary publication directly characterizes A0A314KVN4 / DTX40_3; annotation rests on MATE family inference (multidrug and toxic compound extrusion antiporters that often transport plant secondary metabolites) plus the nicotine-pathway genomic and co-expression evidence placing this candidate as the attenuata ortholog of tobacco MATE1 in the A622-MATE1-beta-GD1 late-pathway module - the exact transported metabolite (nicotine, nicotine glucoside, or another intermediate) and the precise membrane localization remain experimentally unresolved.