Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
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Original discovery paper identifying BECN1 as BCL2-interacting protein with antiviral activity
"These findings demonstrate that Beclin is a novel Bcl-2-interacting cellular protein that may play a role in antiviral host defense."
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
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UVRAG identified as BECN1-binding protein that regulates autophagy
"UVRAG, a tumour suppressor candidate... associates with the Beclin1-Bcl-2-PI(3)KC3 multiprotein complex, where UVRAG and Beclin1 interdependently induce autophagy"
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.
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BCL2/BCL-XL bind BECN1 BH3 domain to inhibit autophagy, not regulate apoptosis
"The anti-apoptotic proteins Bcl-2 and Bcl-X(L) bind and inhibit Beclin-1, an essential mediator of autophagy... BH3-only proteins and pharmacological BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin-1 and Bcl-2 or Bcl-X(L)."
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
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BNIP3/BNIP3L BH3 domains induce autophagy by disrupting BCL2-BECN1 complex WITHOUT inducing cell death
"we propose a model in which the atypical BH3 domains of hypoxia-induced BNIP3/BNIP3L have been designed to induce autophagy by disrupting the Bcl-2-Beclin1 complex without inducing cell death"
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
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ATG14-dependent phosphorylation at Ser90/93 is required for maximal autophagy
"We map these novel phosphorylation sites to serines 90 and 93 and demonstrate that phosphorylation at these sites is necessary for maximal autophagy."
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BECN1 membrane association controls autophagosome size and number
"We identified a unique domain in beclin-1, conserved in the yeast homologue Atg6, which is involved in membrane association and, unexpectedly, controls autophagosome size and number in yeast."
IRGM governs the core autophagy machinery to conduct antimicrobial defense.
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IRGM assembles ULK1 and BECN1 to form autophagy initiation complexes
"IRGM interacts with ULK1 and Beclin 1 and promotes their co-assembly thus governing the formation of autophagy initiation complexes."
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BECN1 phosphorylation at Ser93/96 by AMPK activates autophagy
"IRGM interacts with ULK1 and Beclin 1 and promotes their co-assembly"
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.
Human VPS34 and p150 are Rab7 interacting partners.
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Regulation of membrane traffic by phosphoinositide 3-kinases.
Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1.
Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells.
Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11.
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
The IKK complex contributes to the induction of autophagy.
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
Network organization of the human autophagy system.
Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
Endogenous HMGB1 regulates autophagy.
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus.
Inhibition of autophagy by TAB2 and TAB3.
PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.
A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.
Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection.
The VMP1-Beclin 1 interaction regulates autophagy induction.
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.
Identification of a candidate therapeutic autophagy-inducing peptide.
Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.
Control of autophagic cell death by caspase-10 in multiple myeloma.
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
Decorin causes autophagy in endothelial cells via Peg3.
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.
Placental autophagy regulation by the BOK-MCL1 rheostat.
Intrinsically disordered regions in autophagy proteins.
Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages.
Targeting γ-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.
NRBF2 regulates macroautophagy as a component of Vps34 Complex I.
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.
Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
A kinase-independent role for EGF receptor in autophagy initiation.
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
The BECN1 N-terminal domain is intrinsically disordered.
ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance.
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.
Architecture of the human interactome defines protein communities and disease networks.
ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication.
Global Proximity Interactome of the Human Macroautophagy Pathway.
Hepatitis B virus X Protein Promotes Liver Cancer Progression through Autophagy Induction in Response to TLR4 Stimulation.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
GRB2 is a BECN1 interacting protein that regulates autophagy.
Multimodal cell maps as a foundation for structural and functional genomics.
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex.
ISGylation of host proteins
ULK1 phosphorylates AMBRA1:BECN1 complex
Beclin-1 complex phosphorylates PtdIns
AMBRA1:DYNLL binds BECN1 complex
BECN1 complex dissociates from DYNLL
ULK1 phosphorylates Beclin-1
Beclin-1 complex translocates to ER
Phagophore extends from PI3P-enriched structure
USP13 deubiquitinates BECN1
SARS-CoV-2 ORF8 binds BECN1
Deep research report on BECN1