Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay.
Role of the C-terminal extensions of alpha-crystallins. Swapping the C-terminal extension of alpha-crystallin to alphaB-crystallin results in enhanced chaperone activity.
Alteration of protein-protein interactions of congenital cataract crystallin mutants.
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P gamma C-crystallin.
alphaB-crystallin competes with Alzheimer's disease beta-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35.
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
HSPB7 is a SC35 speckle resident small heat shock protein.
Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.
The eye lens chaperone alpha-crystallin forms defined globular assemblies.
Synergistic efficacy of LBH and alphaB-crystallin through inhibiting transcriptional activities of p53 and p21.
Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers.
N-terminal domain of alphaB-crystallin provides a conformational switch for multimerization and structural heterogeneity.
Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract.
Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach.
The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture.
Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties.
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.
Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
Preferential and specific binding of human αB-crystallin to a cataract-related variant of γS-crystallin.
Widespread macromolecular interaction perturbations in human genetic disorders.
Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.
αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.
The novel αB-crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy.
Architecture of the human interactome defines protein communities and disease networks.
A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.
HSF1-mediated gene expression
Dynamic fibrillar assembly of alphaB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM
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CRYAB exists in highly polydisperse oligomers (approximately 10-40 subunits) with rapid subunit exchange dynamics important for chaperone activity
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The conserved N-terminal IXI-like motif (NT-IXI) engages the ACD hydrophobic groove, governing assembly; perturbation transforms native assemblies into reversible elongated helical fibrils resolved by cryo-EM
Mutation of CRYAB encoding a conserved mitochondrial chaperone and antiapoptotic protein causes hereditary optic atrophy
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CRYAB E105K (within the ACD) causes autosomal dominant optic atrophy by reducing oligomer formation, chaperone activity, and interactions with cytochrome c and VDAC
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CRYAB deficiency/mutation leads to increased apoptosis, mitochondrial dysfunction, and impaired OXPHOS assembly in retinal ganglion cells
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis
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LBH enhances p38 phosphorylation and CRYAB Ser59 phosphorylation; p38 inhibitor abolishes LBH-induced CRYAB pS59
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Phosphorylated CRYAB facilitates NRF2 upregulation/nuclear translocation and contributes to ferroptosis resistance via GPX4 in cardiomyocytes
Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin
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CRYAB is upregulated in mature hiPSC-derived cardiomyocytes and is secreted via exosomes
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CRYAB siRNA knockdown significantly inhibits HUVEC migration and tube formation, demonstrating CRYAB is necessary for pro-angiogenic paracrine effects
Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling
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Stressed cardiomyocytes secrete EVs enriched in protein-quality-control factors including CRYAB during pathological remodeling
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CRYAB accumulates in recipient cells exposed to stressed cardiomyocyte-derived EVs
Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling
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Ser59 phosphorylation shifts CRYAB condensates toward less dynamic, more aggregate-prone states (condensatopathy), mislocalizing cytoskeletal and sarcomeric client proteins
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Phosphomimetic S59D behaves similarly to cardiomyopathy mutant R120G in condensate behavior; S59A mitigates aggregate toxicity
Falcon deep research for human CRYAB
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Falcon synthesis supports CRYAB/HSPB5 as an ATP-independent small heat shock protein holdase chaperone whose oligomerization, phosphorylation, cytoskeletal clients, and mitochondrial anti-apoptotic roles define its core and context-specific functions.