Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes.
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity.
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.
Functional association between SLAP-130 and SLP-76 in Jurkat T cells.
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region.
Towards a proteome-scale map of the human protein-protein interaction network.
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.
Expression, refolding and crystallizations of the Grb2-like (GADS) C-terminal SH3 domain complexed with a SLP-76 motif peptide.
Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction.
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.
Charting the molecular network of the drug target Bcr-Abl.
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.
Cooperative interactions at the SLP-76 complex are critical for actin polymerization.
A human MAP kinase interactome.
Next-generation sequencing to generate interactome datasets.
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.
Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions.
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
A proteome-scale map of the human interactome network.
Phospho-tyrosine dependent protein-protein interaction network.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Maximizing binary interactome mapping with a minimal number of assays.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
Phosphorylation of SLP-76
Recruitment of SLP-76 to Gads
Phosphorylation of PLC-gamma1
Recruitment of PLC-gamma1 to SLP-76
Recruitment of ITK to SLP-76
Disassociation of PLC-gamma1 from SLP-76
Recruitment of GADS:SLP-76 to p-5Y-LAT
Phosphorylation of SLP-76 by p-SYK
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
Activation of RAC1 by VAV2/3
Recruitment of VAV and BTK to p-SLP-76
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Phosphorylation of TEC kinases by p-SYK
Activation of RAC1 by VAV
Phosphorylation and activation of VAV
Hydrolysis of PIP2 by PLCG
Phosphorylation of SLP-76 by p-SYK
Autophosphorylation of PAK
Autophosphorylation of BTK/ITK
Recruitment of PAK to the membrane by binding active RAC1
Recruitment of VAV to p-SLP-76
Syk activation leads to SLP-76 activation
Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.
Weak SLP-76/PLC-γ1 interaction fine-tunes T cell receptor signal strength to optimize T cell responsiveness.
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Falcon deep research report for human LCP2