Gene Ontology annotation through association of InterPro records with GO terms.
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic Gene Ontology annotation based on Rhea mapping.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase.
BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling.
BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling.
The Arabidopsis transthyretin-like protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE 1.
Ultraviolet-B signalling: Arabidopsis brassinosteroid mutants are defective in UV-B regulated defence gene expression.
Heterodimerization and endocytosis of Arabidopsis brassinosteroid receptors BRI1 and AtSERK3 (BAK1).
Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1.
Brassinosteroid homeostasis in Arabidopsis is ensured by feedback expressions of multiple genes involved in its metabolism.
Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1.
Interaction of Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase with a homolog of mammalian TGF-beta receptor interacting protein.
The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE1.
Mapping the Arabidopsis organelle proteome.
Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane.
BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways.
Attenuation of brassinosteroid signaling enhances FLC expression and delays flowering.
BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis.
Differential degradation of PIN2 auxin efflux carrier by retromer-dependent vacuolar targeting.
Tyrosine phosphorylation of the BRI1 receptor kinase emerges as a component of brassinosteroid signaling in Arabidopsis.
Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana.
Brassinosteroids control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development.
Increased leaf size: different means to an end.
Structural basis of steroid hormone perception by the receptor kinase BRI1.
The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2.
Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1.
Deactivation of the Arabidopsis BRASSINOSTEROID INSENSITIVE 1 (BRI1) receptor kinase by autophosphorylation within the glycine-rich loop.
Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics.
BSKs are partially redundant positive regulators of brassinosteroid signaling in Arabidopsis.
Inverse modulation of plant immune and brassinosteroid signaling pathways by the receptor-like cytoplasmic kinase BIK1.
Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
The Brassinosteroid-Activated BRI1 Receptor Kinase Is Switched off by Dephosphorylation Mediated by Cytoplasm-Localized PP2A B' Subunits.
Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling.
An extracellular network of Arabidopsis leucine-rich repeat receptor kinases.
Putrescine metabolism modulates the biphasic effects of brassinosteroids on canola and Arabidopsis salt tolerance.
A role for brassinosteroid signalling in decision-making processes in the Arabidopsis seedling.
R-SNARE protein YKT61 mediates root apical meristem cell division via BRASSINOSTEROID-INSENSITIVE1 recycling.
A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction.
Deep research on BRI1 function
Falcon (Edison Scientific) deep research report: Arabidopsis thaliana BRI1 (BRASSINOSTEROID INSENSITIVE 1; UniProt O22476; At4g39400)
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"The UniProt accession **O22476** corresponds to **Arabidopsis thaliana BRI1**, a **leucine-rich repeat receptor-like kinase (LRR-RLK)** that functions as the canonical **cell-surface brassinosteroid (BR) receptor** and signals with **SERK co-receptors** (notably **BAK1/AtSERK3**)."
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"**Brassinosteroids** are plant steroid hormones that regulate growth and development by being perceived at the **plasma membrane (PM)** by BRI1."
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"BRI1 is a **cell-surface LRR-RLK** whose ectodomain contains an **island domain** that participates directly in steroid binding; work on early BR signaling established that the **island domain together with LRR22** forms the steroid-binding motif."
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"In Arabidopsis, BRI1 forms a complex with a **SERK family co-receptor**, especially **BAK1/AtSERK3**, and the complex becomes active through **sequential transphosphorylation** between the two kinase domains."
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"BRI1 is a receptor kinase primarily classified as a Ser/Thr kinase, but it also displays **tyrosine phosphorylation** (dual-specificity behavior) as part of BR signaling regulatory logic."
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"A 2024 synthesis emphasizes that BR perception and key early signaling steps occur at the **cell surface**, with BRI1 functioning as a PM receptor whose abundance and activity are tightly controlled."
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"Activated BRI1 phosphorylates RLCKs including BSK1 and CDG1; BSK1 is phosphorylated at Ser230, and CDG1 at Ser44, Ser47, and Ser234, with Ser234 important for CDG1 activation."
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"BRI1 undergoes regulated internalization by multiple routes including **clathrin-mediated endocytosis** (AP-2/T-PLATE-associated) and a **clathrin-independent** pathway (FLOT1-associated), followed by endosomal trafficking (e.g., via **TGN/EE**) and vacuolar degradation."
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"BRI1 is organized in **PM nanodomains** that are distinct from certain immune receptor nanodomains (e.g., FLS2)."