Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:16677074

pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.

Recombinant human ERp72 has peptide thiol-disulfide oxidase activity with pH dependence similar to PDI.

PMID:12475965

A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

ERp72 is a component of a large ER multichaperone complex associated with unassembled immunoglobulin heavy chains.

PMID:7916014

Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation.

ERp72 cross-links to thyroglobulin, BiP and GRP94 in thyroid cells during thyroglobulin maturation.

PMID:19995400

Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.

ERp72 is released by human and mouse platelets and relocates to the cell surface after activation.

file:HORSE/PDIA4/PDIA4-bioinformatics/RESULTS.md

Horse PDIA4 vs human PDIA4 sequence comparison

Horse A0A3Q2IEH6 is full length (645 aa), 90% identical to human P13667 with all three CGHC sites, signal peptide and a C-terminal REEL motif conserved.

file:HORSE/PDIA4/PDIA4-bioinformatics/human-P13667-uniprot.txt

UniProt record for human PDIA4 (P13667)

file:HORSE/PDIA4/PDIA4-uniprot.txt

UniProt record for horse PDIA4 (A0A3Q2IEH6)