Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity

Electronic Gene Ontology annotations created by ARBA machine learning models

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein.

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein.

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein.

No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice.

Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.

Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle.

Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.

Crystal structures of the Dab homology domains of mouse disabled 1 and 2.

Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.

Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake.

Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.

Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein.

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.

Spatial segregation of gamma-secretase and substrates in distinct membrane domains.

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos.

Regulation of NMDA receptor trafficking by amyloid-beta.

Homo- and heterodimerization of APP family members promotes intercellular adhesion.

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein.

Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein.

Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.

Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.

Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage.

Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

The in vivo brain interactome of the amyloid precursor protein.

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis.

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.

Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.

Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

Tau reduction prevents Abeta-induced defects in axonal transport.

Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles.

Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.

LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.

Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.

A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis.

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.

Amyloid precursor proteins are constituents of the presynaptic active zone.

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites.

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.

Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.

TREM2 regulates microglial cell activation in response to demyelination in vivo.

Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.

Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing.

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension.

Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons.

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.

Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus.

Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene.

Deep research report on App

Falcon deep research report on mouse App function