GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservation of the subcellular location

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

PMID:30318146

The 7q11.23 protein DNAJC30 interacts with ATP synthase and links mitochondria to brain development.

Native human-brain immunoprecipitation associates DNAJC30 with ATP synthase; human-bait two-hybrid assays identify MT-ATP6 and ATP5MC2 interactions.
Macaque immunogold supports inner-membrane localization. Mouse knockout affects neuronal morphology, respiration and ATP production; multigene Williams-Beuren samples have a separate interpretive scope.

PMID:32296183

A reference map of the human binary protein interactome.

Validated binary interaction records support a heterogeneous DNAJC30 partner panel; native physiological roles of these interactions remain unresolved.

PMID:33465056

Impaired complex I repair causes recessive Leber's hereditary optic neuropathy.

DNAJC30-deficient human cells retain assembled complex I but show impaired rapid turnover of selected N-module subunits, supporting a repair role rather than a de-novo assembly requirement.
Complex-V activity, abundance and turnover were unaffected in the tested human systems, limiting a universal ATP-synthase regulatory mechanism.

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Human-cell mitochondrial fractionation and membrane-association proteomics identify DNAJC30 as an integral mitochondrial protein.

file:human/DNAJC30/DNAJC30-uniprot.txt

UniProt entry Q96LL9 (DJC30_HUMAN), DnaJ homolog subfamily C member 30, mitochondrial

One 226-residue precursor is recorded, with predicted mitochondrial targeting and a membrane anchor. Processing coordinates do not define separate splice products.
The curated FUNCTION section links assistance in N-module subunit turnover and degradation after oxidative damage to PMID:33465056; regulation of respiration and ATP synthesis is recorded by similarity. These evidence attributions are distinct from the predicted sequence features.

"subunits damaged by oxidative stress"

file:human/DNAJC30/DNAJC30-bioinformatics/MitoCoP-DNAJC30.json

Reproducible DNAJC30 target measurements from PMID:34800366 Table S1

The hash-checked original workbook identifies Q96LL9/DNAJC30 in protein group 9379 and classifies the target as mitochondrial and integral. The extract retains original coordinates, column labels and quantitative values; it does not determine inner-versus-outer membrane topology.