Falcon (Edison Scientific Literature) deep research on GADD45A covering checkpoint control via Cdc2/Cyclin B1, MAP3K4-mediated p38/JNK MAPK signaling, DNA damage response, apoptosis, and recent 2024-2025 evidence including a TNBC drug-repurposing study and a cardiac role.
Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseases.
Nifuratel Induces Triple-Negative Breast Cancer Cell G2/M Phase Block and Apoptosis by Regulating GADD45A.
MAP3K4 kinase action and dual role in cancer.
GADD45A suppression contributes to cardiac remodeling by promoting inflammation, fibrosis and hypertrophy.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression.
Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control.
Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.
CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.
TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.
Towards a proteome-scale map of the human protein-protein interaction network.
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
Toward an understanding of the protein interaction network of the human liver.
Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway.
Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Multimodal cell maps as a foundation for structural and functional genomics.
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.
TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription
FOXO-mediated transcription of cell cycle genes
Deep research on GADD45A function
Cyberian deep research on GADD45A function covering structure, localization, RNA binding, and protein interactions
Gadd45 in stress signaling, cell cycle control, and apoptosis
GADD45 proteins - central players in tumorigenesis
Characterisation of the interaction between PCNA and Gadd45
Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
GADD45 induction of a G2/M cell cycle checkpoint
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation
Gadd45a Is an RNA Binding Protein and Is Localized in Nuclear Speckles
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
Gadd45 in stress signaling
The crystal structure and dimerization interface of GADD45gamma
GADD45A: With or without you.
Genomic instability in Gadd45a-deficient mice