Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.
FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate.
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis.
Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.
Klotho converts canonical FGF receptor into a specific receptor for FGF23.
Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro.
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Activated FGFR1 mutants and fusions bind PLCG1
Activated FGFR1 mutants and fusions phosphorylate PLCG1
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
FGFR1c binds to Klotho-bound FGF23
Autocatalytic phosphorylation of FGFR4
Autocatalytic phosphorylation of FGFR3c
Autocatalytic phosphorylation of FGFR2c
Autocatalytic phosphorylation of FGFR1c
Autocatalytic phosphorylation of Klotho-bound FGFR1c
Autocatalytic phosphorylation of FGFR3c P250R mutant
FGFR3c P250R mutant binds to ligand with enhanced affinity
FGFR1c P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
FGFR2c mutants bind an expanded range of ligands
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR2 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR3
Activated FGFR1 phosphorylates PLCG1
Activated FGFR4 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR2
Activated FGFR2 binds PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR1
Activated FGFR1 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR3 phosphorylates PLCG1
Activated FGFR3 binds PLCG1
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 phosphorylates FRS2
Activated FGFR2 binds FRS2
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds SHC1
Activated FGFR2:p-SHC1 binds GRB2:SOS1
Activated FGFR2 phosphorylates SHC1
Activated FGFR3 phosphorylates FRS2
Activated FGFR3 binds FRS2
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3:pFRS binds GRB2:SOS1
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR1 binds FRS2
Activated FGFR1 binds FRS3
Activated FGFR1 binds SHC1
Activated FGFR1 phosphorylates FRS2
Activated FGFR1 phosphorylates FRS3
Activated FGFR1 phosphorylates SHC1
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR1:p-FRS binds GRB2:SOS1
Activated FGFR1:p-FRS phosphorylates PPTN11
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1:p-SHC1 binds GRB2:SOS1
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds FRS3
Activated FGFR2 phosphorylates FRS3
Activated FGFR2 phosphorylates PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:pFRS binds GRB2:SOS1
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 binds FRS3
Activated FGFR3 binds SHC1
Activated FGFR3 phosphorylates FRS3
Activated FGFR3 phosphorylates PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR3 phosphorylates SHC1
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
FGFR1-associated PI3K phosphorylates PIP2 to PIP3
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2-associated PI3K phosphorylates PIP2 to PIP3
FGFR3-associated PI3K phosphorylates PIP2 to PIP3
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-CBL:GRB2 binds p-FRS2:activated FGFR3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
p-4Y-PLCG1 dissociates from activated FGFR2 mutants
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3 point and translocation mutants phosphorylate PLCG1
Activated FGFR3 point and translocation mutants bind PLCG1
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants
Activated FGFR3 point, translocation and fusion mutants bind FRS2
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate FRS2
Activated FGFR1 mutants bind FRS2
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR1 mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate PLCG1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 mutants bind FRS2
Activated FGFR2 mutants bind PLCG1
Activated FGFR1 binds FLRT1,2,3
RAS GEFs promote RAS nucleotide exchange
GALNT3 transfers GalNAc to FGF23
GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region
FAM20C phosphorylates FAM20C substrates
Regulation of fibroblast growth factor-23 signaling by klotho.
α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
The parathyroid is a target organ for FGF23 in rats.
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.
UniProt entry Q9GZV9 (FGF23, human)
Deep research report for human FGF23 (falcon provider)