GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:22516433

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

Plasma-microvesicle proteomics provides the source context, but the specific CIB2 detection remains unresolved.

PMID:22779914

Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.

Purified human CIB2 binds Ca and Mg and interacts with alphaIIb and alpha7B cytoplasmic fragments.

PMID:23023331

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.

CIB2 binds cellular partners, attenuates ATP-evoked calcium responses and localizes in sensory structures; retinal perturbation evidence includes a separate fly model.

PMID:26173970

Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells.

R66W and F91S retain the measured localization and cellular buffering properties despite their disease association.

PMID:26426422

A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.

Human CIB2 R186W retains measured localization and whirlin association but impairs the wild-type calcium-response attenuation in the tested cellular assay.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

The CIB2 affinity-purification experiment identifies PARD3B association, with gene-level protein inference and assay-specific construct limits.

PMID:36115835

Quantitative fragmentomics allow affinity mapping of interactomes.

The canonical CIB2 tail binds multiple PDZ fragments in direct affinity assays; the results do not establish all native full-length or alternative-product interactions.

PMID:18611855

Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy.

Mouse Cib2 binds calcium and an alpha7B integrin tail and localizes to muscle membrane specializations.

PMID:28663585

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.

CIB2 associates with TMC1/2 and is necessary for normal hair-cell mechanotransduction, with mutant-specific effects on interaction.

PMID:34089643

CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.

Cib2 mutations alter channel localization and resting opening; the tested TMC2 adaptation protocols remain unchanged.

PMID:40000792

Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction.

Purified human CIB2 binds two TMC1 regions, with metal-dependent partner affinity and a resolved domain-complex structure.

PMID:39889697

Mechano-electrical transduction components TMC1-CIB2 undergo a Ca(2+)-induced conformational change linked to hearing loss.

The abstract reports calcium-dependent TMC1–CIB2 conformational changes and altered mouse MET conductance after CIB2 calcium-site perturbation.

PMID:34162842

CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function.

CIB2 associates with RHEB and Raptor, restrains mTORC1 signaling and supports RPE processing, with secondary photoreceptor consequences.

PMID:39773557

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.

Human CIB2 simultaneously binds TMC1 N-terminal and loop fragments; monomeric solution behavior and modeled channel stabilization are distinguished from cellular self-association.

PMID:42427029

Rescue of stereocilia architecture and hearing function by AAV-CIB2 and AAV-CIB3 in a mouse model of recessive deafness DFNB48.

AAV-mediated mouse Cib2 or human CIB3 expression improves hearing and hair-cell outcomes in Cib2-deficient mice.

file:human/CIB2/CIB2-source-evidence.json

CIB2 source and assay scope index