Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.
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LPCAT2 was cloned and characterized as an acetyl-CoA:lyso-PAF acetyltransferase
"A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase."
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The enzyme catalyzes both PAF production and membrane PC synthesis
"Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF."
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LPCAT2 is inducible in inflammatory cells
"The enzyme was induced by bacterial endotoxin (lipopolysaccharide), which was suppressed by dexamethasone treatment."
Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers
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LPCAT2/AGPAT11 has AGPAT activity (LPA to PA conversion)
"In vitro enzymatic activity using lysates of Human Embryonic Kidney-293 cells infected with recombinant AGPAT11/LPCAT2/lyso platelet-activating factor-acetyltransferase cDNA adenovirus show that the protein has an AGPAT activity but lacks glycerol-3-phosphate acyltransferase enzymatic activity."
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Lacks GPAT activity
"the protein has an AGPAT activity but lacks glycerol-3-phosphate acyltransferase enzymatic activity."
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Localizes to ER in CHO and HeLa cells
"When AGPAT11/LPCAT2/lyso platelet-activating factor acetyltransferase cDNA was expressed in CHO and HeLa cells, the protein product localized to the endoplasmic reticulum."
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Upregulated in breast, cervical, and colorectal cancers
"Expression of AGPAT11 mRNA was significantly upregulated in human breast, cervical, and colorectal cancer tissues, indicating its adjuvant role in the progression of these cancers."
Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
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LPCAT2 localizes to both ER and lipid droplets
"Here, we show in various mammalian cell lines that both enzymes additionally localize to lipid droplets (LDs), which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly PC."
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LPCAT2 has dual ER and lipid droplet localization enabled by monotopic topology
"This dual localization is enabled by the monotopic topology of these enzymes demonstrated in this study."
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Catalyzes local PC synthesis on lipid droplets
"Furthermore, we show that LDs have the ability to locally synthesize PC and that this activity correlates with the LPCAT1 and -2 expression level."
A reference map of the human binary protein interactome
2-acyl LPC is acylated to PC by LPCAT
1-acyl LPC is acylated to PC by LPCAT
Acyl chain remodelling of PC
Deep research on LPCAT2 function