The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila.

Interactions of a Rel protein with its inhibitor.

Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer.

Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor.

Electronic Gene Ontology annotations created by ARBA machine learning models

Annotation inferences using phylogenetic trees

Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product.

The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output.

The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist.

A Toll-dependent Bre1/Rad6-cact feedback loop in controlling host innate immune response.

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.

Gene Ontology annotation through association of InterPro records with GO terms

Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function.

Tamo selectively modulates nuclear import in Drosophila.

Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila.

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators.

The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export.

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function.

The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response.

Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module.

Regulated nuclear import of Rel proteins in the Drosophila immune response.

A serpin regulates dorsal-ventral axis formation in the Drosophila embryo.

The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in Drosophila.

COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis.

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.

Self-organized shuttling: generating sharp dorsoventral polarity in the early Drosophila embryo.

Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila.

Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.

Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Phosphorylated DL/DIF dimer activates transcription

Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus

Combined Automated Annotation using Multiple IEA Methods

CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'

Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'

DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex'

CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'

Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex'

Phosphorylated CACT is degraded in the cytosol

DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.

The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

LncRNA-CR11538 Decoys Dif/Dorsal to Reduce Antimicrobial Peptide Products for Restoring Drosophila Toll Immunity Homeostasis.

Interaction of lncRNA-CR33942 with Dif/Dorsal Facilitates Antimicrobial Peptide Transcriptions and Enhances Drosophila Toll Immune Responses.

Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.

Muscle structure and innervation are affected by loss of Dorsal in the fruit fly, Drosophila melanogaster.

Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila.

Alternative NF-κB Isoforms in the Drosophila Neuromuscular Junction and Brain.

Hemolymph-dependent and -independent responses in Drosophila immune tissue.

Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense.

The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

CtBP-independent repression in the Drosophila embryo.

Functional conservation of Rel binding sites in drosophilid genomes.

The Friend of GATA Transcriptional Co-Regulator, U-Shaped, Is a Downstream Antagonist of Dorsal-Driven Prohemocyte Differentiation in Drosophila.

NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.

HMG boxes of DSP1 protein interact with the rel homology domain of transcription factors.

Falcon deep research report for dl

UniProtKB entry P15330 (dl)

FlyBase gene description for dl__P15330 (DROME)