Reviewed all 71 incoming contexts without discarding qualifiers, supporting entities or partner isoform labels: 15 ACCEPT, 9 TOO_GENERAL, 4 KEEP_AS_NON_CORE, 3 UNDECIDED, 39 REMOVE and 1 MODIFY. No NEW annotation is proposed. The 39 generic binding removals preserve the positive physical contacts; the specific beta-catenin row is refined to GO:0008013.
The source and product guide records the primary-reading boundaries, including the distinct human and mouse products, unresolved tagged-construct species, historical PAINT family, marker-specific localization uncertainty and inaccessible methyl-SELEX supplement. The source-use ledger counts repeated paper-derived rationales separately and budgets the whole description, core, reference notes, guide and new quotations together.
All three unresolved rows remain UNDECIDED. No action was selected merely to satisfy a validator. All core claims have primary evidence; no provider report was fabricated or attached to suppress a missing deep-research advisory. The provisional DRAFT status must be recomputed by the native tooling.
The private intake used official UniProt/QuickGO records and a bounded open-PR snapshot. Before native preparation, recheck current main, namespace, source ownership and overlapping changes. Existing source files and history records must remain immutable. Any later native fetch must be authentic, missing-only for publications and reconciled against these exact raw contexts. This proposal is not evidence that native fetching, validation, rendering or publication has already occurred.
The genuine repository fetch reproduced all 71 reviewed machine objects, all 16 exported columns and the single 524-residue human product. Nine missing publication caches were acquired normally; all twelve existing source objects remained exact. Five literal primary excerpts passed normal-cache reconciliation; three required whitespace-only adaptation. Normal-cache access flags are recorded separately from the independently read originals. Genuine history, default validation, strict GOA matching, status agreement and HTML rendering passed.
Computed status remains DRAFT because the validator warns about GO:1990837: the broad electronic assertion is TOO_GENERAL, while the specific methyl-SELEX experimental assertion remains UNDECIDED because its exact supplement entry was not recovered. This is a source-specific evidence boundary, not a change made to suppress a warning. All 71 decisions remain individually reviewed, with three explicit uncertainties and no PENDING or NEW annotation.
Mouse Glis2 localizes predominantly to the nucleus; deletion reporters must be distinguished from full-length activity. PMID:11741991(https://pubmed.ncbi.nlm.nih.gov/11741991/)
Glis2 recruits CtBP1 and HDAC3 during repression; nuclear puncta alone do not identify splicing-factor compartments. PMID:16326862(https://pubmed.ncbi.nlm.nih.gov/16326862/)
The mouse renal study links Gli1 antagonism to Snai1/Wnt4 regulatory DNA. This direct mechanism supports the existing human orthology assignments. PMID:21816948(https://pubmed.ncbi.nlm.nih.gov/21816948/)
Physical beta-catenin binding is established; a separate physiological process annotation requires its own assessment. PMID:17289029(https://pubmed.ncbi.nlm.nih.gov/17289029/)
The preceding action counts and unresolved-row discussion are historical and superseded by this follow-up. The three former UNDECIDED judgments are revised on evidence and term specificity: the broad DNA-binding claim is retained, while source-specific assay details remain unverified; the two compartment assignments exceed the inspected localization resolution. UNDECIDED remains valid for unresolved assertions, including inaccessible relevant evidence. It is not restricted to wholly inaccessible papers.
The existing single transcriptional core now includes the two accepted pathway-regulation transfers. No NEW annotation or fusion-product function is asserted. The review records separate beta-catenin process and reviewer-raised fusion-product questions. Normal-cache access flags describe cached availability; the source guide identifies independently inspected originals. Native status and checks must be recomputed after application.
Default validation, exact GOA matching and status agreement passed. The native status computation is COMPLETE with no validation warnings; the previous DRAFT discussion remains historical. The updater reports existing-status mismatches without changing them, so its computed value was applied explicitly and then rechecked. All 71 incoming machine contexts, all 21 normal sources and the prior history remain unchanged. Genuine EDIT history and current HTML were produced. No NEW annotation or source acquisition was introduced.