Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility.
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5.
Enterohemorrhagic Escherichia coli O157 outer membrane vesicles induce interleukin 8 production in human intestinal epithelial cells by signaling via Toll-like receptors TLR4 and TLR5 and activation of the nuclear factor NF-kappaB.
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.
Defective MyD88 does not oligomerize within the complex of activated TLR5
IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR
TRAF6 binds to hp- IRAK1 or p-IRAK2
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
IRAK4 autophosphorylation within the complex activated TLR:MyD88
MyD88 forms a complex with the activated TLR receptor
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
MyD88 oligomerization within the complex of activated TLR:MyD88