Annotation inferences using phylogenetic trees
GO annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic GO annotation from UniProtKB-KW mapping
Combined Automated Annotation using Multiple IEA Methods
Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands.
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iRhom1 interacts with TGF-alpha family ligands and is an ER/Golgi membrane rhomboid homolog.
"Characterization of a human rhomboid homolog, p100hRho/RHBDF1"
Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.
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RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in cancer cells.
"Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells"
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.
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Rhomboid pseudoproteases use ER quality control to regulate intercellular (EGF/ADAM17) signaling; iRhom1 has no protease activity.
"Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling"
iRhom1 regulates proteasome activity via PAC1/2 under ER stress.
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
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iTAP/FRMD8 is an iRhom interactor controlling TNF secretion by stabilizing iRhom/TACE.
"iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE"
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
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FRMD8 stabilizes the iRhom/ADAM17 sheddase complex to promote inflammatory and growth-factor signaling.
"FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex"
A reference map of the human binary protein interactome.
UniProt entry Q96CC6 (RHBDF1)
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iRhom1 lacks serine protease activity (no catalytic Ser-720).
"Lacks serine protease activity as it lacks the catalytic Ser"
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Regulates ADAM17, a sheddase of EGF-receptor ligands.
"Regulates ADAM17 protease, a sheddase of the epidermal growth"