Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.
Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.
An efficient mammalian cell-free translation system supplemented with translation factors.
p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins.
The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.
GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells.
The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.
Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation.
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The endoplasmic reticulum stress response in aging and age-related diseases.
eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.
Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
Architecture of the human interactome defines protein communities and disease networks.
Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA.
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
A reference map of the human binary protein interactome.
QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Binding of human Cdc123 to eIF2γ.
The HRI branch of the integrated stress response selectively triggers mitophagy.
Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR).
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
Formation of translation initiation complexes containing mRNA that does not circularize
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK
eIF2:GTP is hydrolyzed, eIFs are released
De novo formation of eIF2:GTP
Met-tRNAi binds to eIF2:GTP to form the ternary complex
Formation of eIF2:GDP:eIF2B intermediate
Formation of the 43S pre-initiation complex
p-PKR dimer phosphorylates eIF2-alpha
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)
RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.