Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Expression and stabilization of the MCT-1 protein by DNA damaging agents.
A human protein-protein interaction network: a resource for annotating the proteome.
MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles.
Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.
Next-generation sequencing to generate interactome datasets.
DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.
Multimodal cell maps as a foundation for structural and functional genomics.
Falcon deep research report for MCTS1
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MCTS1 forms a heterodimer with DENR and acts on post-termination 40S ribosomal subunits to promote re-initiation after uORFs and to recycle ribosomes; loss of MCTS1 causes stalled post-termination 40S ribosomes and 80S queueing. MCTS1-dependent reinitiation is required for translation of a selective set (~200-240) of uORF-containing mRNAs, most notably JAK2, with physiological relevance to IFN-gamma immunity.