Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
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Established C. elegans autophagy pathway including AUT10/atg-18 ortholog
"Autophagy genes are essential for dauer development and life-span extension in C. elegans."
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Autophagy essential for dauer morphogenesis and lifespan extension
"Autophagy genes are essential for dauer development and life-span extension in C. elegans."
Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans.
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Autophagy genes including atg-18 promote clearance of polyQ aggregates
"Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans."
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Inactivation accelerates aggregate accumulation and exacerbates dysfunction
"Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans."
Autophagy is required for necrotic cell death in Caenorhabditis elegans.
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.
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RNAi against atg-18 results in defective cell corpse clearance
"The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans."
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Links autophagy to phagosome maturation
"The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans."
Autophagy and apoptosis are redundantly required for C. elegans embryogenesis.
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.
The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.
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ATG-18 plays distinct role from EPG-6 in autophagosome formation
"The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes."
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Both are PI3P-binding WD40 proteins
"The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes."
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Established hierarchical relationships of autophagy genes
"The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes."
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FRRG motif required for PI binding
"The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes."
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.
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ATG-18 recruited to phagosome outer surface
"Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell."
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PI3P binding via FRRG motif required for recruitment and function
"Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell."
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ATG-18 promotes RAB-5 recruitment and phagosome maturation
"Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell."
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Functions in phagocyte for cell corpse degradation
"Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell."
PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
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ATG-18 association with autophagosomes depends on PI3P levels
"PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation."
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MTM-3 loss increases ATG-18 autophagic association
"PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation."
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
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atg-18(gk378) hypersensitive to Cry5B pore-forming toxin
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
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atg-18 required for xenophagic degradation of toxin
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
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atg-18 required for membrane pore repair
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
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atg-18 transcriptionally upregulated by Cry5B exposure
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.
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atg-18/WIPI1/2 required for germline stem cell proliferation
"A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development."
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Promotes cell-cycle progression via DAF-16/FOXO
"A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development."
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Functions in DAF-2/insulin signaling pathway
"A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development."
The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan.
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ATG-18 expressed in neurons and intestinal cells
"The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan."
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Regulates neurotransmitter/neuropeptide release
"The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan."
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Controls lifespan in response to dietary restriction
"The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan."
Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.
Deep research report on atg-18