ACO2 (YJL200C, P39533) notes

• UniProt renamed to homocitrate dehydratase [UniProt:P39533 "Catalyzes the reversible dehydration of (R)-homocitrate to"].
• Fazius et al. 2012: Aco2p prefers homoaconitate ~950-fold over aconitate PMID:23106124; does not contribute to TCA cycle PMID:23106124; K610 (Arg in TCA aconitases) explains specificity.
• Chen et al. 2019 (minor isozymes): aco2 deletion 25% fitness defect on trehalose; aconitate slightly up, aKG down PMID:30834327. Interpreted as aconitase role — conflicts with Fazius; could reflect lysine/homocitrate effects.
• No GO term for homocitrate dehydratase (RHEA:26101); GO:0004409 homoaconitate hydratase is the Lys4p reaction (EC 4.2.1.36). Proposed new term; NEW involved_in L-lysine biosynthetic process (GO:0009085).

Curation: aconitate hydratase rows kept as non-core (residual activity); glyoxylate-cycle and cytosol rows are YeastCyc paralog/superpathway artefacts.