Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:18238778

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.

Used by UniProt (ECO:0000269) as an experimental source for GPAT1 (GPAM) function and catalytic activity, including the core sn-glycerol-3-phosphate + acyl-CoA -> 1-acyl-LPA + CoA reaction. The abstract foregrounds the paralog AGPAT6/GPAT4.

PMID:19075029

The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.

Cited by UniProt (ECO:0000269) for a GPAM catalytic activity acylating 1-acyl-lysophosphatidylglycerol to diacyl-phosphatidylglycerol; basis for the IMP annotations to GPAT activity and phosphatidylglycerol biosynthesis. Abstract foregrounds ALCAT1.

PMID:32296183

A reference map of the human binary protein interactome.

Systematic human binary interactome (HuRI) screen; source of the GPAM (Q9HCL2) protein-binding IPI, corresponding to the GPAM-CIDEB (Q9UHD4) interaction recorded in UniProt.

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

High-throughput mitochondrial proteomics detecting GPAM in the high-confidence human mitochondrial proteome; corroborates mitochondrial localization.

Reactome:R-HSA-1482695

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)

Reactome:R-HSA-1483166

Synthesis of PA

Reactome:R-HSA-1655837

Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)

Reactome:R-HSA-75109

Triglyceride biosynthesis

Reactome:R-HSA-75886

glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]

Reactome:R-HSA-8932020

GPAM gene expression is stimulated by RUNX1 and ESR1

PMID:36522428

Structural basis of the acyl-transfer mechanism of human GPAT1.