Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
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IBA annotations for extracellular space and innate immune response based on PANTHER family PTN000667087
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Orthology to characterized CLIP-domain proteases in Drosophila supports immune and secretion annotations
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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UniProt keywords Immunity, Innate immunity, Protease, Serine protease, Hydrolase mapped to corresponding GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
A genetic module regulates the melanization response of Anopheles to Plasmodium
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CLIPB4 RNAi knockdown reduces melanization of P. berghei ookinetes in resistant L3-5 strain
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Combined CLIPB4/CLIPB17 knockdown causes 52-fold reduction in melanized ookinetes
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CLIPB4 is dispensable for ookinete elimination in susceptible G3 strain (lysis mechanism)
CLIPB4 Is a Central Node in the Protease Network that Regulates Humoral Immunity in Anopheles gambiae Mosquitoes
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CLIPB4 cleaves and activates CLIPB8
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CLIPB4 interacts with SRPN2 which inhibits its activity
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CLIPB4 knockdown reduces melanization after microbial challenge
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CLIPB4 knockdown rescues CLIPB8 depletion after microbial challenge
An easter-like serine protease from Anopheles gambiae exhibits changes in transcript abundance following immune challenge
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CLIPB4 (AgSp14D1) is expressed in fat body, cuticle, thorax and ovaries
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Expression is induced by blood meal and bacterial infection
Insight into the structural hierarchy of the protease cascade that regulates the mosquito melanization response
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CLIPB4 functions upstream in melanization cascade, controlling CLIPB10 cleavage
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CLIPB4 biochemically cleaves cSPH CLIPA8 in vitro
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CLIPB4 knockdown reduces MelASA-measured melanization after E. coli challenge
Wolbachia infection-responsive immune genes suppress Plasmodium falciparum infection in Anopheles stephensi