PANTHER family review PTHR48012: IBA propagation assessment for cdc7
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
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The protein serine/threonine kinase activity IBA is correct, but the MAPK cascade IBA is an over-propagation from the PANTHER STE20/SPS1-PAK family; Cdc7 functions in the SIN, not a MAPK cascade.
"ring constriction is triggered by the septum initiation network (SIN), an SPB-associated GTPase-regulated kinase cascade that coordinates exit from mitosis with cytokinesis"
Automatic Gene Ontology annotation based on Rhea mapping
Asymmetry of the spindle pole bodies and spg1p GAP segregation during mitosis in fission yeast.
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Cdc7 localizes to both SPBs early in mitosis and to only one pole during anaphase; asymmetric Spg1 inactivation by the Cdc16-Byr4 GAP underlies the asymmetric retention of Cdc7.
"cdc7p is located on both spindle pole bodies early in mitosis, but only on one during the later stages of anaphase."
Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.
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Active GTP-Spg1 binds Cdc7 and causes its translocation to SPBs; Byr4 localization to SPBs controls Cdc7 localization and septation.
"As cells enter mitosis, Spg1 accumulates in an active, GTP-bound form and binds the Cdc7 protein kinase to cause Cdc7 translocation to SPBs."
S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.
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The Sid4-Cdc11 scaffold anchors SIN components, including Cdc7, at the SPB and is required for septation initiation signaling.
"cdc11p is required for the localization of all the known SIN components, except sid4p, to the SPB."
The genome sequence of Schizosaccharomyces pombe.
Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.
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Cdc7 kinase activity is required for mitotic hyperphosphorylation of the SIN scaffold Cdc11, identifying Cdc11 as a functional substrate and linking Cdc7 to SIN activation.
"We demonstrate that mitotic hyperphosphorylation of cdc11p requires the activity of cdc7p and that its dephosphorylation at the end of mitosis requires PP2A-par1p."
Etd1p is a novel protein that links the SIN cascade with cytokinesis.
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The SIN is an SPB-associated GTPase-regulated kinase cascade; Cdc7 is asymmetrically recruited to the SPB that maintains active Spg1 and acts upstream of Sid1-Cdc14 and Sid2-Mob1 to trigger ring constriction.
"The protein kinase Cdc7p is asymmetrically recruited to the SPB that maintains the activated form of Spg1p"
The fission yeast MO25 protein functions in polar growth and cell separation.
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SIN-regulated proteins (and Cdc7) are recruited to one of the two SPBs during anaphase and to the division site during cytokinesis.
"it is recruited to one of the two spindle pole bodies during anaphase and to the division site during cytokinesis."
The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.
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The SIN, including Cdc7, is required for spore formation in meiosis; Cdc7 associates with the meiotic SPB in meiosis II coincident with forespore membrane deposition.
"The protein kinases Sid1p and Cdc7p do not associate with the spindle pole body until meiosis II, when forespore membrane deposition begins."
Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.
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Spg1-GTP binds and recruits Cdc7 to the SPB; SPB-localized Cdc7 promotes Sid2 activation, and Spg1/Cdc7 are active at just one SPB during cytokinesis.
"Once activated, Spg1-GTP binds the Cdc7 kinase and recruits it to the spindle pole body (SPB; Sohrmann et al., 1998)."
Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.
SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
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Cdc7 and Sid1 localize asymmetrically to the newly duplicated SPB in late anaphase; the SIP/PP2A complex propagates this asymmetry by promoting Cdc7 accumulation at the new SPB.
"Two of the SIN kinases, Cdc7p and Sid1p, localize asymmetrically to the newly duplicated SPB in late anaphase."
Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe.
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During meiosis Cdc7 localizes to the SPB and is degraded after meiosis II in a Dma1-dependent manner, reflecting stage-specific SIN regulation.
"the degradation of Cdc7p, Cdc11p and Sid4p occurs after the second meiotic division and depends upon the ubiquitin ligase Dma1p"
The septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.
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Cdc7-GFP accumulates at spindle pole bodies upon SIN activation, after which SIN activity disperses type 1 (Cdr2/Mid1) nodes.
"Activating the SIN in interphase cells dispersed Cdr2p and anillin Mid1p from type 1 nodes a few min after the SIN kinase Cdc7p-GFP accumulated at spindle pole bodies."
The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast.
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cdc7 encodes an essential protein kinase required to initiate division septum formation and cytokinesis; DNA synthesis and mitosis are unaffected in cdc7 mutants, and the overexpression multiple-septation phenotype requires kinase activity.
"These findings indicate that the p120cdc7 protein kinase plays a key role in initiation of septum formation and cytokinesis in fission yeast"
The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.
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The Spg1 GTPase interacts with Cdc7 and is an essential, dosage-dependent inducer of septum formation, acting upstream of Cdc7 in the SIN.
"The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe"
Asymmetric segregation on spindle poles of the Schizosaccharomyces pombe septum-inducing protein kinase Cdc7p.
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Cdc7 has no discrete interphase localization, associates with both SPBs early in mitosis, then is retained on one pole during anaphase B; Spg1 activity is required for Cdc7 localization in vivo but not for its in vitro kinase activity.
"Cdc7p shows no discrete localization during interphase, but early in mitosis it associates with both spindle pole bodies and, as the spindle extends, is seen on only one pole of the spindle during anaphase B."