tam41 (SPBC1A4.06c, UniProt O74339) notes
- Mitochondrial CDS, Tam41 family (PANTHER PTHR13619:SF0), unrelated to bbl1 [UniProt:O74339].
- S. pombe Tam41 crystal structures and kinetics: "Here we show that Tam41 adopts sequential catalytic mechanism" PMID:31178220; UniProt records KM 0.26 mM CTP, 0.094 mM PA from this work [UniProt:O74339].
- Membrane association: "The C-terminal region of SpTam41 contains a positively charged amphipathic helix crucial for membrane association and participates in binding phospholipids." PMID:31178220 (abstract-only cache).
- S. cerevisiae: "Tam41 directly catalyzes the conversion of PA to CDP-DAG in the presence of CTP" and "Tam41 is a peripheral IM protein facing the matrix" PMID:23623749.
- Consistent with yeast TAM41 review (MF GO:0004605; BP CDP-DAG + cardiolipin biosynthesis; CC inner membrane + matrix).
- GO-CAM 67086be200000363: tam41 GO:0004605 occurs_in mitochondrial matrix, part_of CDP-DAG biosynthesis. Module annoton uses mitochondrial inner membrane; both defensible (peripheral, matrix side).
- PA binding/CL binding IDA kept as non-core; mitochondrial membrane organization (IC) kept as non-core (indirect via cardiolipin).