Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential.
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mitfb is expressed in the RPE, epiphysis and olfactory bulb, but not in neural crest melanoblasts.
"mitfb is expressed in the epiphysis and olfactory bulb where mitfa is not"
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The mitfb protein rescues nacre melanophores when expressed from the mitfa promoter.
"mitfb, but not a zebrafish ortholog of the closely related gene tfe3, can rescue neural crest melanophore development in nacre/mitfa mutant embryos when expressed via the mitfa promoter"
Subfunctionalization of duplicate mitf genes associated with differential degeneration of alternative exons in fish.
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Each fish Mitf protein corresponds to one tetrapod MITF isoform, with degeneration of alternative exons.
"In the teleost lineage subfunctionalization of mitf genes after duplication at least 100 million years ago is associated with the degeneration of alternative exons"
Pigmentation pathway evolution after whole-genome duplication in fish.
Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development.
A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.
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In medaka mitfb has the more central role in melanophore development.
"suggesting that mitfb, but not mitfa, plays the more central role in melanophore development in medaka"
Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages.
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mitfb partially compensates for loss of mitfa in xanthophores, especially in fins.
"These phenotypes suggest that mitfb partially compensates for the loss of mitfa (though not tfec) in xanthophores and especially so in the fins."
MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts.
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mitfa, mitfb and tfec are jointly required for RPE pigmentation.
"These findings indicate that the redundant functions of Mitfa, Mitfb, and Tfec are not only essential for the specification of diverse pigment cell types but also critical for RPE pigmentation."