GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB Subcellular Location vocabulary mapping

GO_REF:0000107

Automatic Assertion of Orthology

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:16103875

Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells.

PMID:25578875

Structure and assembly pathway of the ribosome quality control complex.

NEMF senses nascent-chain occupancy of 60S via the exposed P-site tRNA and recruits/stabilizes Listerin, defining the RQC complex assembly pathway.

PMID:33406423

Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival.

Mammalian NEMF (RQC2 homolog) adds non-templated C-terminal alanine-rich (CAT) tails to nonstop translation products; CAT tailing promotes ubiquitination for proteasomal degradation, and failure causes nascent-chain aggregation and apoptosis.

PMID:33909987

Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.

NEMF performs tRNA-Ala-dependent alanine tailing of stalled nascent chains; in addition to assisting Listerin, the Ala tail acts as a C-degron recognized by CRL2-KLHDC10 and RCHY1/PIRH2 C-end-rule E3 ligases.

PMID:35452614

Ribosome-associated quality-control mechanisms from bacteria to humans.

Review summarizing RQC including NEMF/Rqc2 as the 60S-sensing, CAT-tailing RQC subunit.

Reactome:R-HSA-9948318