Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
Human VPS34 and p150 are Rab7 interacting partners.
Regulation of membrane traffic by phosphoinositide 3-kinases.
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Network organization of the human autophagy system.
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.
Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).
Inhibition of autophagy by TAB2 and TAB3.
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG.
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking.
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
-
Human ATG14 knockout impairs Parkin-mediated mitochondrial clearance after depolarization; the full paper also tests BECN1 abundance and complex stability.
"mitochondrial clearance was greatly reduced in hAtg14 knockout cells"
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.
NRBF2 regulates macroautophagy as a component of Vps34 Complex I.
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
A kinase-independent role for EGF receptor in autophagy initiation.
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
IRGM governs the core autophagy machinery to conduct antimicrobial defense.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.
A reference map of the human binary protein interactome.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Global Proximity Interactome of the Human Macroautophagy Pathway.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex.
Structural pathway for PI3-kinase regulation by VPS15 in autophagy.
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.
ULK1 phosphorylates AMBRA1:BECN1 complex
Beclin-1 complex phosphorylates PtdIns
AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex
BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
ULK1 phosphorylates Beclin-1
Beclin-1 complex translocates to the ER
The phagophore extends from the PIP3-enriched structure
SARS-CoV-2 8:class I MHC binds BECN1
BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Palmitoylation of ULK1 by ZDHHC13 plays a crucial role in autophagy.
The human autophagy-initiating complexes ULK1C and PI3KC3-C1.
UniProtKB record for ATG14
Manual primary full-text check of PMID:21062745
Falcon literature research on human ATG14