Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:21047783

Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}.

ASXL2 enhances PPARgamma activity in the reported adipocyte model.

"overexpression of ASXL2 greatly enhanced rosiglitazone-induced PPARγ activity and enhanced adipogenesis."

PMID:35512704

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Reactome:R-HSA-5689630

BAP1 binds BAP1-interacting complex

Reactome:R-HSA-5690790

Histone H2A is dubiquitinated by the PR-DUB complex

PMID:26416890

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.

BAP1 assembles with distinct ASXL regulatory partners.

"BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2"

PMID:26739236

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

All three human ASXL DEUBAD domains can directly activate BAP1.

"These results establish that the DEUBAD domains in all human ASXL paralogs can stimulate BAP1 activity."

PMID:40729547

Unconventional structure and function of PHD domains from additional sex combs-like proteins.

The purified ASXL2 PHD participates in stable MBD6 association.

"a stable heterodimeric complex between the ASXL2 PHD and MBD6 MBD domain is formed in solution and involves zinc binding."

PMID:30664650

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation.

BAP1-associated core complexes support transcriptional activation.

"an enzymatically active BAP1-associated core complex (BAP1.com) containing one of the redundant ASXL proteins."

PMID:36180891

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

ASXL PHD regions support MBD5/6-dependent complex assembly.

"MBD5 and MBD6) that bind to the C-terminal PHD fingers of the large scaffold subunits ASXL1-3 and stabilize the BAP1 complex at the chromatin."