Falcon deep research report for LSM1
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Falcon supports LSM1 as the defining cytoplasmic Lsm1-7-Pat1 complex subunit coupling deadenylated mRNA recognition to decapping and 5' to 3' decay.
"The Lsm1-7 ring plus Pat1 is a key module that links 3' end status to decapping: Pat1/Lsm1-7 binds oligoadenylated 3' ends and helps recruit/activate the decapping enzyme."
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
A Sm-like protein complex that participates in mRNA degradation.
Yeast Sm-like proteins function in mRNA decapping and decay.
Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins.
The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.
High-definition macromolecular composition of yeast RNA-processing complexes.
Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.
Proteome survey reveals modularity of the yeast cell machinery.
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes.
A role for Q/N-rich aggregation-prone regions in P-body localization.
High-quality binary protein interaction map of the yeast interactome network.
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
Global analysis of yeast mRNPs.
Proteome-wide protein interaction measurements of bacterial proteins of unknown function.
Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis.
Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.
RNA-dependent interactome allows network-based assignment of RNA-binding protein function.
The social and structural architecture of the yeast protein interactome.