Use of the ND evidence code for Gene Ontology (GO) terms
Proteome-wide analysis of phospho-regulated PDZ domain interactions.
-
Phospho-regulated PDZ interaction screen with phosphomimetic C-terminal peptides.
"We computationally designed an oligonucleotide library encoding human C-terminal peptides containing known or predicted Ser/Thr phosphosites and phosphomimetic variants thereof."
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative fragmentomics allow affinity mapping of interactomes.
-
Quantitative PDZ-PBM affinity screen.
"Here, we measure the affinities of 65,000 interactions involving PDZ domains and their target PDZ-binding motifs (PBM) within a human interactome region particularly relevant for viral infection and cancer."
Progressive Degenerative Myopathy and Myosteatosis in ASNSD1-Deficient Mice.
-
Asnsd1-null mice develop a degenerative myopathy.
"Mice with an inactivating mutation in the gene encoding asparagine synthetase domain containing 1 (ASNSD1) develop a progressive degenerative myopathy that results in severe sarcopenia and myosteatosis."
-
ASNSD1 is most highly expressed in skeletal muscle.
"ASNSD1 is conserved across many species, and whole body gene expression surveys show maximal expression levels of ASNSD1 in skeletal muscle."
UniProt entry Q9NWL6 (ASNSD1_HUMAN)
Affinage mechanistic annotation for ASNSD1 (human)