Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain.
A genomic perspective on plant transcription factors.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
The COP/DET/FUS proteins-regulators of eukaryotic growth and development.
Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1.
bZIP transcription factors in Arabidopsis.
Genome-wide analysis of gene expression reveals function of the bZIP transcription factor HY5 in the UV-B response of Arabidopsis.
CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis.
Functional profiling reveals that only a small number of phytochrome-regulated early-response genes in Arabidopsis are necessary for optimal deetiolation.
Intrinsically unstructured N-terminal domain of bZIP transcription factor HY5.
phyA dominates in transduction of red-light signals to rapidly responding genes at the initiation of Arabidopsis seedling de-etiolation.
PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis.
SALT TOLERANCE HOMOLOG2, a B-box protein in Arabidopsis that activates transcription and positively regulates light-mediated development.
Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling de-etiolation in darkness.
Identification of a novel cis-regulatory element for UV-B-induced transcription in Arabidopsis.
Integration of light and abscisic acid signaling during seed germination and early seedling development.
LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination.
The clock protein CCA1 and the bZIP transcription factor HY5 physically interact to regulate gene expression in Arabidopsis.
Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis.
BBX32, an Arabidopsis B-Box protein, functions in light signaling by suppressing HY5-regulated gene expression and interacting with STH2/BBX21.
The Arabidopsis B-BOX protein BBX25 interacts with HY5, negatively regulating BBX22 expression to suppress seedling photomorphogenesis.
Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development.
Promoter-based integration in plant defense regulation.
MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper.
An Arabidopsis gene regulatory network for secondary cell wall synthesis.
Short Hypocotyl in White Light1 Interacts with Elongated Hypocotyl5 (HY5) and Constitutive Photomorphogenic1 (COP1) and Promotes COP1-Mediated Degradation of HY5 during Arabidopsis Seedling Development.
Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation.
CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping.
HY5 Interacts with the Histone Deacetylase HDA15 to Repress Hypocotyl Cell Elongation in Photomorphogenesis.
The Arabidopsis HY5 gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl.
Arabidopsis bZIP protein HY5 directly interacts with light-responsive promoters in mediating light control of gene expression.
Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development.
Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development.
Deep research on HY5 function
Falcon (Edison Scientific) deep research report: Arabidopsis thaliana HY5 (At5g11260; UniProt O24646)
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"**HY5 is a sequence-specific DNA-binding transcription factor** of the **bZIP family**. It directly binds light-responsive promoter elements—classically **ACGT-centered G-box/light-responsive elements (LREs)**—to activate light-induced gene expression programs."
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"Mechanistically, HY5 functions as a **positive regulator of photomorphogenesis** (de-etiolation) downstream of multiple photoreceptors, with loss-of-function hy5 mutants displaying long hypocotyl phenotypes under diverse light conditions."
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"HY5 acts primarily in the **nucleus**. In a key Plant Cell study, **GFP–HY5 fluorescence localized exclusively to nuclei** across cell types (cotyledons, hypocotyl, roots), and its nuclear localization was reported as not being strongly light regulated."
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"In **darkness**, the E3 ubiquitin-ligase-associated factor **COP1** accumulates in the nucleus and promotes **proteasome-dependent HY5 turnover**, repressing photomorphogenesis."
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"Classic examples include **RBCS-1A** (photosynthetic gene) and **CHS** (chalcone synthase; flavonoid biosynthesis), where direct promoter binding and HY5-dependence were demonstrated in early mechanistic studies."
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"HY5’s regulatory scope extends beyond a few markers: genome-scale analyses summarized in authoritative syntheses indicate **thousands of HY5-bound genes** and broad effects on seedling development and metabolism."
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"HY5 is also a key transcriptional regulator under UV-B. In a landmark Plant Cell study, **COP1 was required for low-UV-B responses** and **HY5 gene activation**; under supplementary UV-B, **COP1 and HY5 accumulated in the nucleus**, and UV-B-triggered flavonoid accumulation and genome-wide UV-B-responsive expression changes were largely blocked in cop1 mutants. This positions HY5 as a major effector of UV-B acclimation programs (e.g., via CHS/flavonoid pathways)."