Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
Cell surface-associated elongation factor Tu mediates the attachment of Lactobacillus johnsonii NCC533 (La1) to human intestinal cells and mucins.
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins.
Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.
Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Structure and function of lipopolysaccharide binding protein.
Monocyte antigen CD14 is a phospholipid anchored membrane protein.
27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide.
SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation.
Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14.
Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer.
The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.
Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14.
Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice.
CD14 is a cell-activating receptor for bacterial peptidoglycan.
Human CD14 mediates recognition and phagocytosis of apoptotic cells.
Transfer of LPS onto TLR4
MyD88 forms a complex with TIRAP:activated TLR2/4
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
Multiple IRAK1 autophosphorylation steps
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
TRIF:activated TLR3/TLR4 complex recruits RIP1
TLR6:TLR2 is recruited to ligand:CD14:CD36
TLR1:TLR2 is recruited to ligand:CD14
Endocytosis of TLR4:LY96:LPS:CD14
Activated TLR2/4 interacts with MAL (TIRAP)
TIRAP is phosphorylated by BTK
TRAF3 binds TICAM1:activated TLR4 complex
Auto-ubiquitination of TRAF3
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Activated TLR2/4:TIRAP interacts with BTK
TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
TLR1/2 ligand binds to CD14
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14
TLR4-induced ripoptosome assembly
Caspase-8 processing within TLR4 complex
RIP3 binds TRIF to mediate necroptosis
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4
Defective MyD88 does not oligomerize within the activated TLR2/4 complex
Defective MyD88 does not bind MAL(TIRAP):TLR2/4
Exocytosis of secretory granule membrane proteins
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
Activation of TAK1 complex bound to activated TLR4 complex
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
Activated TLR4:TICAM1 recruits TRAF6
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
IKBKG subunit of IKK complex binds polyubiquinated RIP1
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
Phosphorylated TAK1 leaves activated TLR receptor complex
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
TBK1 is phosphorylated within the activated TLR4 complex
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
OPTN binds TBK1 within the activated TLR4 complex
IKKε (IKBKE) is ubiquitinated within the activated TLR4
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex
RSV F binds TLR4:LY96:CD14
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.
The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.
Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.
CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes.
Falcon deep research report on CD14