Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Functional requirement of p23 and Hsp90 in telomerase complexes.
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.
Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis.
A CD14-independent LPS receptor cluster.
Intestinal epithelial cells secrete exosome-like vesicles.
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release.
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.
Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex.
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase.
S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex.
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Characterization of a novel interaction between the secretory Na+-K+-Cl- cotransporter and the chaperone hsp90.
Dissection of the mitochondrial import and assembly pathway for human Tom40.
Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.
Molecular recognition via coupled folding and binding in a TPR domain.
S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
A human protein-protein interaction network: a resource for annotating the proteome.
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays.
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
Akt and CHIP coregulate tau degradation through coordinated interactions.
HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway.
The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Binding of Hsp90 to tau promotes a conformational change and aggregation of tau protein.
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT.
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.
Defining the membrane proteome of NK cells.
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Chaperone-mediated autophagy: molecular mechanisms and physiological relevance.
S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
A human MAP kinase interactome.
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.
The client protein p53 adopts a molten globule-like state in the presence of Hsp90.
Proteomic characterization of the human sperm nucleus.
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.
Toward an understanding of the protein interaction network of the human liver.
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1.
Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.
A proteome-scale map of the human interactome network.
Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide.
C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
MEK drives BRAF activation through allosteric control of KSR proteins.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington's disease.
Maximizing binary interactome mapping with a minimal number of assays.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Interactome dynamics of RAF1-BRAF kinase monomers and dimers.
Multimodal cell maps as a foundation for structural and functional genomics.
The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.
Dynamic activation of endothelial nitric oxide synthase by Hsp90.
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers
HSP90 is inactivated by binding to benzaquinoid ansamycins
Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37
Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants
Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors
Binding of EGF to ligand-responsive EGFR mutants
EGF-induced dimerization of ligand-responsive EGFR mutants
Spontaneous dimerization of ligand-responsive EGFR mutants
Binding of SHC1 to p-6Y-EGFR mutants
Binding of CBL to ligand-responsive p-6Y-EGFR mutants
Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants
PLCG1 binds to ligand-responsive p-6Y-EGFR mutants
Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
EGFRvIII mutant binds chaperone proteins HSP90 and CDC37
Ligand-independent dimerization of EGFRvIII mutant
Trans-autophosphorylation of EGFRvIII mutant dimers
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
BH2 binding can lead to eNOS uncoupling
Uncoupled eNOS favours the formation of superoxide
CHIP (STUB1) mediates ubiquitination of ERBB2
CUL5 mediates ubiquitination of ERBB2
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
HSP90 binds eNOS:Caveolin-1:CaM complex
AKT1 binds eNOS complex via HSP90
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
SCARF1:ligand is endocytosed
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
Dissociation of cytosolic HSF1:HSP90 complex
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
Transphosphorylation of pLIMK1
Dimerization of LIMK1 by Hsp90
HSF1-mediated gene expression
Dissociation of HSF1:HSP90 complex in the nucleus
HSP90AA1 binds p-6Y-VEGFR2
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118
CRK binds BCAR1 and or PXN
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
DOCK180:ELMO exchanges GTP for GDP, activating RAC1
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407
HSP90:FKBP4:PTGES3 binds HSF1 trimer
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
RAB3IP stimulates nucleotide exchange on RAB8A
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein
ATP binding to HSP90 triggers conformation change
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
Binding of GRB2:GAB1 complex to p-EGFRvIII mutant
Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII
Binding of SHC1 to p-5Y-EGFRvIII
Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII
PLC-gamma 1 binds to p-EGFRvIII mutant
EGFRvIII does not bind CBL
Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
Phosphorylation of SHC1 by p-5Y-EGFRvIII
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex
Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
EGFRvIII cancer variant does not bind EGF ligand
Expression of STAT3-upregulated cytosolic proteins
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex
ESTG binds ESR1:chaperone complex
Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
ERBB2 KD mutants bind trastuzumab
ERBB2 KD mutants heterodimerize
ERBB2 KD mutants bind TKIs
Resistant ERBB2 KD mutants do not bind trastuzumab
Resistant ERBB2 KD mutants do not bind AEE788
ERBB2 KD mutants do not bind osimertinib
Resistant ERBB2 KD mutants do not bind lapatinib
Resistant ERBB2 KD mutants do not bind neratinib
ERBB2 T862A does not bind sapitinib
ERBB2 T798M does not bind afatinib
ERBB2 T733I does not bind tesevatinib
ERBB2 ECD mutants heterodimerize with EGFR
ERBB2 ECD mutants bind trastuzumab
ERBB2 ECD mutants bind TKIs
ERBB2 TMD/JMD mutants bind trastuzumab
ERBB2 TMD/JMD mutants hetrodimerize
ERBB2 TMD/JMD mutants bind TKIs
ERBB2 TMD/JMD mutants bind pertuzumab
ERBB2 TMD/JMD mutants do not bind pertuzumab
NR3C1 binds NR3C1 agonists
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)
Androgens binds AR (in the HSP90 chaperone complex)
ESTG binds ESR2:chaperone complex
HSP90 binds TBK1 and IRF3
MAVS:TOMM70 recruits HSP90:TBK1:IRF3
ESR1 binds ESR1 antagonists
NR3C2 binds NR3C2 antagonists
P4 bind PGR (in the HSP90 chaperone complex)
NR3C2 binds fludrocortisone
PGR binds PGR antagonists
UniProtKB entry P07900 (HS90A_HUMAN)
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
https://www.linkgroup.hu/docs/pcs/03ejb.pdf
Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site.
Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system.
Early response of heat shock proteins to functional overload of the soleus and plantaris in rats and mice.
Hsp90aa1: a novel target gene of miR-1 in cardiac ischemia/reperfusion injury.
Altered energy intake and the amplitude of the body temperature rhythm are associated with changes in phase, but not amplitude, of clock gene expression in the rat suprachiasmatic nucleus in vivo.
The role of heat shock proteins in inflammatory injury induced by cold stress in chicken hearts.
Paternal exposure to testis cancer chemotherapeutics alters sperm fertilizing capacity and affects gene expression in the eight-cell stage rat embryo.
Upregulation and intrarenal redistribution of heat shock proteins 90alpha and 90beta by low-sodium diet in the rat.
Heat shock protein 90 alpha and 14-3-3η in postmenopausal osteoporotic rats with varying levels of serum FSH.
Influence of Mild Chronic Stress and Social Isolation on Acute Ozone-Induced Alterations in Stress Biomarkers and Brain-Region-Specific Gene Expression in Male Wistar-Kyoto Rats.
Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus.
Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes.
Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy.
Effects of heat shock protein 90 expression on pectoralis major oxidation in broilers exposed to acute heat stress.
Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of Bid in hypothermic preservation rat hearts.
Bisdemethoxycurcumin mitigates traumatic brain injury in rats by modulating autophagy and oxidative stress via heat shock protein 90 alpha family class A member 1-mediated nuclear translocation of transcription factor EB.
Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway.
Biological responses of three-dimensional cultured fibroblasts by sustained compressive loading include apoptosis and survival activity.