AMPKalpha (SNF1A; CG3051; UniProt O18645) notes

• Single catalytic alpha subunit of fly AMPK; activated by AMP and ATP depletion, Thr184 phosphorylation
  PMID:12093363
• Heterotrimer: RNAi of alpha, beta or gamma ablates activity PMID:12093363.
• Active phospho-AMPKalpha nuclear in stressed cells PMID:12093363.
• Substrates: Gigas/TSC2 Ser1338 PMID:25826530; MRLC in visceral muscle PMID:20478298; Atg1 (Bombyx, conserved sites) PMID:36493962.
• Polarity controversy: PMID:17486097 vs
  PMID:24337115. -> polarity annotations UNDECIDED (AMPKalpha, alc).
• Starvation: PMID:20862213
• TORC1: AMPK lowers mTOR activity PMID:36899949; GOA "positive regulation of TORC1 signaling" MODIFY to negative (consistent across the LKB1/AMPK module genes).
• ARBA "nematode pharyngeal pumping" removed (taxon-inappropriate).
• Deep research: the first falcon run was killed (exit 137); a retry produced AMPKalpha-deep-research-falcon.md, which agrees that AMPKalpha [file:DROME/AMPKalpha/AMPKalpha-deep-research-falcon.md "encodes the catalytic alpha subunit of the conserved heterotrimeric AMP-activated protein kinase (AMPK) complex"].