Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
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Foundational study establishing that C. elegans uses ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress.
"C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress"
A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.
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Genome-wide microarray of the C. elegans ER-stress response; hsp-3 (cosmid C15H9.6) is among the tunicamycin-induced genes whose induction is attenuated in xbp-1 mutants (Table I), establishing hsp-3 as an xbp-1-dependent UPR target.
"in C. elegans, the ire-1 and xbp-1 pathway has retained its essential role in upregulating expression of many UPR target genes that are similarly upregulated by the homologous pathway in yeast"
The HSP70 multigene family of Caenorhabditis elegans.
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.
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The paper describes HSP-3 as retained in the ER lumen as biological background, not as a new target localization experiment.
"HSP-1 is predominantly cytosolic, whereas HSP-3 is retained within the ER lumen."
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HSP-3 is an ex-vivo lysate-screen and purified-protein AMPylation substrate of FIC-1, with Thr176 identified in vitro; direct site-specific modification in intact worms is not demonstrated.
"two classes of proteins over-represented amongst the AMPylated fraction of proteins: HSP 70 proteins (HSP-1, HSP-3)"
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The introduction invokes the classical BiP interaction/repression model for IRE-1, ATF-6 and PEK-1; it does not directly assay a ternary HSP-3 sensor complex.
"form a complex with IRE-1, ATF-6 and PEK-1, to preclude activation of UPR-related signaling events"
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HSP-3 contributes to tolerance of chronic ER stress and to innate immunity, based on hypersensitivity of hsp-3 animals to Pseudomonas aeruginosa.
"highlighting a role for HSP-3 in the tolerance of chronic ER stress and innate immunity."
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The two worm BiP paralogs hsp-3 and hsp-4 are assumed to cross-compensate as ER-resident chaperones, framing their functional redundancy.
"elegans encodes two Grp78/BiP homologues, hsp-3 and hsp-4, assumed to cross-compensate for each other in their roles as ER-residing protein chaperones"
Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy.
Identification of BiP as a temperature sensor mediating temperature-induced germline sex reversal in C. elegans.
A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis.
Analysis of the BiP gene and identification of an ER retention signal in Schizosaccharomyces pombe.
Falcon research report on C. elegans HSP-3