Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UniProtKB P10734 (KNIR_DROME): Zygotic gap protein knirps
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Knirps is a transcriptional repressor that binds multiple sites in the eve stripe 3 enhancer and is essential for segmentation by refining gap-gene patterns and establishing pair-rule stripes.
"FUNCTION: Transcriptional repressor. Binds to multiple sites in the eve"
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Knirps has an N-terminal nuclear-receptor C4-type DNA-binding domain with two zinc fingers and belongs to the NR0 subfamily (which lacks a ligand-binding domain).
"Belongs to the nuclear hormone receptor family. NR0"
Cell-cell interaction during Drosophila embryogenesis: novel mechanisms and molecules.
dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein.
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Knirps has two separable repression activities, one dependent on dCtBP binding (C-terminal dCtBP-binding motif) and one dCtBP-independent (N-terminal region).
"One repression activity depends on dCtBP binding, and this function maps to a C-terminal region of Knirps that contains a dCtBP binding motif."
Control of endoreduplication domains in the Drosophila gut by the knirps and knirps-related genes.
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knirps and knirps-related spatially restrict endoreduplication domains in the gut by transcriptionally repressing S-phase genes.
"transcriptionally repress S-phase genes of the cell cycle required for DNA replication"
A protein interaction map of Drosophila melanogaster.
The evolution of arthropod segmentation mechanisms.
Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.
Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm.
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Knirps (kni) is one of the six maternal/gap factors; ChIP with anti-KNI antibodies shows it binds several thousand genomic regions with sequence specificity in the blastoderm.
"these sequence-specific DNA binding proteins bind with quantitatively different specificities to highly overlapping sets of several thousand genomic regions in blastoderm embryos"
Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.
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Groucho is a functional part of the Knirps short-range repression complex, recruited via an eh1-like N-terminal motif, and mediates CtBP-independent repression of even-skipped.
"we report that Groucho is a functional part of the Knirps short-range repression complex."
A Comprehensive Drosophila melanogaster Transcription Factor Interactome.
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Genome-wide yeast two-hybrid interactome among Drosophila sequence-specific transcription factors, reporting 1,983 protein-protein interactions.
"we identified 1,983 protein-protein interactions (PPIs)"
The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development.
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knirps/knirps-related redundantly control tracheal cell migration and dorsal/ventral branch formation, mediating Dpp signaling and repressing spalt.
"knirps/knirps related activity is necessary to mediate DPP signaling which is required for tracheal cell migration and formation of the dorsal and ventral branches"