"IL-12 induces tyrosine phosphorylation of a recently identified STAT family member, STAT4, and show that STAT4 expression is regulated by T-cell activation. Furthermore, we show that IL-12 stimulates formation of a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins and that this complex contains STAT4"

"STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is essential for IL-12 signal transduction... human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis"

"IL-12 induces STAT4 phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 transcriptional activity"

"expression of wild-type STAT4, but not the S721A mutant, restored normal T(H)1 differentiation and IFN-gamma synthesis"

"STAT4 is an essential transcription factor for Th1 cell development"

"the classical JAK (Janus activated kinase)-STAT (signal transducer and activator of transcription) pathway of signalling"

"the N-domain dissociation constants of STAT1, STAT3, and STAT4 differed by more than three orders of magnitude"

"HBXIP is able to activate S100A4 promoter via interacting with STAT4 in breast cancer cells, leading to the up-regulation of S100A4"

"IL-12 works mainly through inducing mostly STAT4 homodimers... IL-23 was shown to activate STAT3 and STAT4 downstream of these receptors... IL-35 utilizes three receptors... the gp130:IL-12Rbeta2 heterodimeric receptor is essential for induced expression of IL-35, which is initiated by a STAT1:STAT4 heterodimer"

"IFN-α/β-mediated STAT4 activation was required for repressing the human IL5 gene, and disrupting STAT4 dimerization reversed this effect. This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-α/β signaling"

"the transcription factor STAT4 is required for the proliferative and IFN-γ effector response by ILC1s and ILC3s, and loss of STAT4 signaling in the innate immune compartment results in an inability to control bacterial growth and dissemination. Interestingly, STAT4 acts acutely as a transcription factor to promote IFN-γ production"

"Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions and is generated by systematic yeast two-hybrid interaction screening of ∼500 ND-related proteins and integration of literature interactions"

"Acetylation of STAT4-K667 is required for JAK2-mediated phosphorylation and activation of STAT4"

"Genome sequencing revealed three novel heterozygous missense gain-of-function variants in STAT4"