ppt1 / coq2 (Q10252, SPAC56F8.04c) review notes

Sources

No deep-research provider output is available (no provider API keys in this
environment). The review rests on the UniProt record and the cached literature;
PMID:11092853 and PMID:24911838 were read in full.

Literature

• Disruption and complementation PMID:11092853
• Mitochondrial localisation PMID:11092853 The paper does not fractionate sub-compartments.
• Human COQ2 complements PMID:24911838
• Overexpression raises UQ PMID:17069919

Audit decisions (2026-11)

• GO:0016020 membrane changed from TOO_GENERAL to MODIFY -> GO:0005743, matching the
  S. cerevisiae and human COQ2 reviews.
• GO:0005743 IDA (PomBase, PMID:11092853) accepted: the paper shows mitochondria only,
  but the inner-membrane claim holds on topology (multi-pass, transit peptide) plus the
  mitochondrial GFP result and the yeast Coq2 EXP evidence; not overruled.
• Core function GO:0008412 agrees with the module's Coq2/UbiA annoton.