Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Cloning of ACP33 as a novel intracellular ligand of CD4.

Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia.

Towards a proteome-scale map of the human protein-protein interaction network.

Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1.

Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.

Next-generation sequencing to generate interactome datasets.

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.

Characterization of maspardin, responsible for human Mast syndrome, in an insect species and analysis of its evolution in metazoans.

A proteome-scale map of the human interactome network.

Widespread macromolecular interaction perturbations in human genetic disorders.

Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons.

Architecture of the human interactome defines protein communities and disease networks.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Multimodal cell maps as a foundation for structural and functional genomics.

The hereditary spastic paraplegia type 21 (SPG21) protein is a RAB7A effector that promotes noncanonical mTORC1-catalyzed TFEB phosphorylation and cytoplasmic retention.

Maspardin/SPG21 controls lysosome motility and TFEB phosphorylation through RAB7 positioning.