Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
-
Provides electronic assignment of ESCRT-III/MVB pathway annotations for CHMP1A from UniProt keywords (e.g. "Endosome", "Membrane", "Protein transport"), consistent with CHMP1A's SNF7-family ESCRT-III role.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.
CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.
Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta.
-
Yeast-two-hybrid study of HCV NS4B interactions in which a CHMP1A interaction was reported. Not directly informative about CHMP1A molecular function; provides only bare protein-binding evidence.
"By using a yeast two-hybrid assay"
The protein network of HIV budding.
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.
A systematic analysis of human CHMP protein interactions; additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.
ESCRT-III recognition by VPS4 ATPases.
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
-
LC-MS/MS proteomics of human urinary exosomes identifies CHMP1A among the exosomal proteome, consistent with CHMP1A's ESCRT-III role in multivesicular-body/exosome biogenesis in renal epithelial cells.
"Normal human urine contains large numbers of exosomes, which are 40- to 100-nm vesicles that originate as the internal vesicles in multivesicular bodies"
Biochemical analyses of human IST1 and its function in cytokinesis.
Essential role of hIST1 in cytokinesis.
Membrane scission by the ESCRT-III complex.
Ab initio protein modelling reveals novel human MIT domains.
-
Bioinformatics identification of novel human MIT (microtubule-interacting-and-transport) domains in proteins including CHMP-binding factors; supports the network of MIT-domain proteins (VPS4, UBPY/USP8, katanin, spastin) that recognise CHMP1A's C-terminal MIM motif.
"Novel MIT domains were confidently identified"
Membrane budding and scission by the ESCRT machinery: it's all in the neck.
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
Toward an understanding of the protein interaction network of the human liver.
-
Yeast-two-hybrid human-liver interactome map reports CHMP1A protein-protein interactions. High-throughput dataset; provides only bare protein-binding evidence, not a specific molecular function.
"Toward an understanding of the protein interaction network of the human liver."
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.
ESCRT machinery is required for plasma membrane repair.
Structure of cellular ESCRT-III spirals and their relationship to HIV budding.
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
ESCRT-III controls nuclear envelope reformation.
Architecture of the human interactome defines protein communities and disease networks.
-
Huttlin et al. BioPlex 2.0 affinity-purification-mass-spectrometry interactome records CHMP1A co-purifying partners consistent with ESCRT-III/CHMP network membership. High-throughput dataset; only bare protein-binding evidence.
"Architecture of the human interactome defines protein communities and disease networks."
A reference map of the human binary protein interactome.
-
Luck et al. HuRI reference binary interactome (yeast two-hybrid) records CHMP1A interactions. High-throughput dataset; only bare protein-binding evidence.
"A reference map of the human binary protein interactome."
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
-
Huttlin et al. BioPlex 3.0 dual (HEK293T/HCT116) affinity-purification-mass-spectrometry interactome records CHMP1A interactions consistent with ESCRT-III community membership. High-throughput dataset; only bare protein-binding evidence.
"Dual proteome-scale networks reveal cell-specific remodeling of the human interactome."
OpenCell Endogenous tagging for the cartography of human cellular organization.
-
OpenCell endogenous split-mNeonGreen tagging with live-cell imaging and IP-MS reports CHMP1A subcellular localization and interaction partners at endogenous levels, supporting the endosomal/vesicular localization and ESCRT-III interaction network.
"OpenCell: Endogenous tagging for the cartography of human cellular organization."
Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).
HCMV Formation of Final Envelopment Complex
Deep research report on CHMP1A