Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.
Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination.
Evidence for simultaneous protein interactions between human Rad51 paralogs.
The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2.
XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding.
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex.
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.
Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.
Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene.
Architecture of the human interactome defines protein communities and disease networks.
Discovery of mutations in homologous recombination genes in African-American women with breast cancer.
XRCC2 mutation causes meiotic arrest, azoospermia and infertility.
XRCC2 Regulates Replication Fork Progression during dNTP Alterations.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
Multimodal cell maps as a foundation for structural and functional genomics.
The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Ligation of DNA and formation of Holliday structures following repair synthesis
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
D-loop formation mediated by PALB2, BRCA2 and RAD51
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding