MRPS7 review notes

Deep research

Automated deep research could not be generated: just deep-research-falcon failed
(Edison API 402 Payment Required; perplexity-lite fallback unavailable) and
just deep-research-openai failed with 401. The review uses the cached literature and
the UniProt record directly.

Literature used

• Menezes et al. 2015, COXPD34 PMID:25556185; rescue in patient fibroblasts PMID:25556185.
• Amunts et al. 2015, human mitoribosome cryo-EM PMID:25838379 (abstract only).
• Greber and Ban 2016 review PMID:27023846 (abstract only).

Curation decisions

• Structural constituent of ribosome, rRNA binding, mitochondrial small ribosomal
  subunit and mitochondrial translation are the core annotations.
• mRNA binding (IBA) and generic RNA binding (HDA) kept as non-core: plausible/true but
  not the demonstrated function of the human protein.
• Mitochondrial inner membrane (Reactome TAS, NAS, ARBA) kept as non-core: reflects the
  peripheral membrane association of the whole mitoribosome; uS7m sits in the
  small-subunit head in the matrix.

Disease context (dismech)

dismech Combined_Oxidative_Phosphorylation_Deficiency_34 used only as a literature lead.