Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Reduced histone biotinylation in multiple carboxylase deficiency patients: a nuclear role for holocarboxylase synthetase.
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.
Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus.
Reduced half-life of holocarboxylase synthetase from patients with severe multiple carboxylase deficiency.
N- and C-terminal domains in human holocarboxylase synthetase participate in substrate recognition.
The N-terminal domain of human holocarboxylase synthetase facilitates biotinylation via direct interaction with the substrate protein.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli.
Isolation and characterization of mutations in the human holocarboxylase synthetase cDNA.
Identification of holocarboxylase synthetase (HCS) proteins in human placenta.
Biotin transport and metabolism
HLCS biotinylates 6x(PCCA:PCCB)
HLCS biotinylates 6xMCCC1:6xMCCC2
HLCS biotinylates PC:Mn2+
HLCS biotinylates ACACA:Mn2+
Defective HLCS does not biotinylate ACACA:Mn2+
Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2
Defective HLCS does not biotinylate PC:Mn2+
Defective HLCS does not biotinylate 6x(PCCA:PCCB)